2021年国家合成生物技术创新中心TIB-VIB合成生物学联合中心博士后招聘公告（天津）

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中国科学院天津工业生物技术研究所是中国科学院与天津市人民政府共建的中国科学院序列研究所，位于天津港保税区空港经济区。天津工业生物所肩负着建立我国工业生物技术创新体系、促进工业绿色升级的历史使命，其战略定位是：面向国民经济主战场，以新生物学为基础，以“人工生物”设计创建为核心，发展生命科学，创新生物技术，引领我国工业生物科技进步，构建工业经济发展的生态路线，打通科技创新价值链，服务于社会经济可持续发展。

国家合成生物技术创新中心(National Innovation Center for Synthetic Biotechnology)是科技部批复建设的第三家国家技术创新中心，由中国科学院与天津市人民政府共建，中国科学院天津工业生物技术研究所(TIBCAS)牵头建设，以建成综合性、开放性、先进性的国家科技平台，形成合成生物技术创新的大联合、大协同、大网络，打造我国合成生物领域战略科技力量，为国家产业技术变革与国际竞争提供战略支撑为建设目标。

一、招聘部门简介(Introduction of TIB-VIB Joint Center of Synthetic Biology)

2020年12月9日，中国科学院天津工业生物技术研究所和比利时弗兰德生物技术研究院(Vlaams Instituut voor Biotechnologie - Flanders Institute of Biotechnology, VIB)成立国家合成生物技术创新中心TIB-VIB合成生物学联合中心(以下简称“联合中心”)。VIB是国际知名的生命科学研究机构，在合成生物学领域拥有世界一流的科技研发和成果转化平台。联合中心旨在推动合成生物中心科技创新和成果转化，推动中国和比利时在合成生物学领域的国际合作，为中比双方生物经济高质量发展贡献力量。

联合中心将聚焦酵母合成生物学与生物技术、基因编辑与基因组重编程、计算生物学与生物设计、底盘细胞构建与蛋白质合成、微生物天然产物合成、植物天然产物途径解析与合成等方向。

The TIB-VIB Joint Center of Synthetic Biology (abbreviated as TV-SynBio), as one of the International Joint Centers of the National Technology Innovation Center of Synthetic Biology, is targeted to provide an exchange and collaboration platform to promote joint R&D, staff exchange, information & resources sharing, technology transfer and industrialization between the Parties. It is proposed to recruit 10-20 postdoctoral researchers focusing on yeast synthetic biology and biotechnology, gene editing and genomic reprogramming, computational biology and bio-design, chassis cell construction and biosynthesis of protein, biosynthesis of natural products in microbes and plants.

二、导师介绍 (Introduction of Professors)

中方导师(Professor from TIB)：

1.王钦宏，主要从事合成细胞工厂的进化与代谢工程研究，有效推进了己二酸、丙酮酸、3-脱氢莽草酸及其衍生的芳香族化合物等生物基化学品的合成生物制造，研制和开发了液滴微流控微生物高通量传感检测与筛选系统已经在Metab Eng，Biotechnol Biofuels，ACS Synth Biol等领域主流SCI期刊发表科研论文60多篇，申请国家发明专利25项。

Prof.Qinhong Wang’s research interests focus on engineering microbial cell factories to improve the production of bio-based productsl for industrialization via genome-wide editing and evolution strategies as well as droplet microfluidic-based high throughput screening strategies in the combination of designing and constructing the target metabolic pathway. Until now he has applied more than 20 patents and published more than 60 papers in Metab Eng, Biotechnol Biofuels, ACS Synth Biol and so on.

Email: wang_qh@tib.cas.cn

2.孙媛霞，从事功能糖与天然活性物质的生物制造，采用合成生物学和酶工程技术和原理，挖掘改造生物元件，设计重构微生物合成代谢途径，创建健康糖、海洋寡糖、天然氮杂糖、百草类天然产物等合成微生物细胞工厂，优化与放大发酵工艺，在ACS Catalysis，Biotechnology advances，Metabolic Engineering等学术刊物上发表SCI论文70余篇，申请专利40余项。

Prof. Yuanxia Sun’ research group works in Biomanufacturing of functional sugars and natural active substances, with a particular focus on using synthetic biology and enzyme engineering technology to mine and transform enzyme components, design and restructure metabolic pathways, create synthetic microbial cell factories such as healthy sugars, marine oligosaccharides, natural azasaccharides, and natural products of herbs, finally optimize and amplify fermentation processes. She has applied 40 patents and published more than 70 journal papers in ACS Catalysis, Biotechnology advances, Metabolic Engineering and so on.

Email:sun_yx@tib.cas.cn

3.田朝光，主要研究方向是真菌合成生物学，具体以丝状真菌为对象，利用合成生物学方法，结合代谢工程技术，构建可用于工业蛋白质和生物基化学品发酵生产的细胞工厂。在Science、PNAS、Metabolic Engineering、PLoS Genetics、Biotechnology for Biofuels等已发表论文40余篇，申请专利20余项，包括PCT专利3项。

Prof. Chaoguang Tian’s research topic is Fungal Synthetic Biology. Using filamentous fungi as system, combining metabolic engineering and synthetic biology, his lab is developing the new generation fungal cell factory for production of industrial proteins and bulk chemicals from renewable feedstock. Until now he has applied more than 20 patents and published more than 40 papers inScience, PNAS, Metabolic Engineering, PLoS Genetics, Biotechnology for Biofuelsand so on.

Email:tian_cg@tib.cas.cn

4.张学礼，从事微生物代谢工程和基因编辑研究，构建微生物细胞工厂生产大宗化学品和植物天然产物，开发碱基编辑器技术用于基因治疗。在Nature Biotechnology, Metabolic Engineering，ACS Synthetic Biology等学术刊物发表SCI论文80余篇。获授权中国专利20项和国际专利24项。4个大宗化学品细胞工厂技术(L-丙氨酸、丁二酸、D-乳酸和缬氨酸)实现产业化，共新增产值30亿元。6个萜类化合物细胞工厂正在与企业进行技术合作。

Prof. Xueli Zhang’s research interests are microbial metabolic engineering and gene editing, including construction of microbial cell factories for production of bulk chemicals and value-added natural products and development of base editor technologies for gene therapy. He has published 80 SCI papers, includingNature Biotechnology, Metabolic EngineeringandACS Synthetic Biology. He has 20 issued Chinese patents and 24 international patents. Four microbial cell factories for production of L-alanine, succinate, D-lactate and L-valine have been commercialized, which contributed to 3 billion Yuan new output value. Six microbial cell factories for production of different terpenoids are cooperating with several companies.

Email:zhang_xl@tib.cas.cn

5.江会锋，从事代谢合成生物学研究，利用合成生物学技术与原理，解析自然界植物复杂生物代谢途径，研究生物合成的基本规律与生物催化原理，设计生物代谢新酶新途径，创建植物天然产物合成微生物细胞工厂，在Nature Communications，ACS Synthetic Biology等学术刊物上发表SCI论文40余篇，申请专利30余项。

Prof. Huifeng Jiang’research topic is Synthetic Biology of Metabolism. By combining omics technologies and synthetic biology, he developed new platforms to dig new genes from Chinese medicinal plants for producing plant natural compounds. Currently, he has constructed more than twenty cell factories for the production of scutellarin, phloretin, diosgenin and so on. Until now he has applied 30 patents and published more than 40 papers includingNature Communications, ACS Synthetic Biology, Molecular Biology and Evolution.

Email:jiang_hf@tib.cas.cn

6.刘涛，主要从事天然产物生物合成研究，包括解析微生物和植物源天然产物复杂生物合成途径，利用合成生物学手段合成新天然产物衍生物，微生物合成植物源天然产物等，在ACS Syn. Biol.，J. Am. Chem. Soc.，Metab. Eng.，Proc. Natl. Acad. Sci.等学术刊物上发表论文30余篇，申请专利20余项。

Prof. Tao Liu's research is focused on natural product biosynthesis. It includes the elucidation of complex multi-step biosynthetic pathways, carried out by bacteria or plants, generation of modified natural product drugs through genetic engineering, microbial synthesis of plant derived natural products through metabolic engineering and synthetic biology. Dr. Liu's has published more than 30 papers, which can be found in ACS Syn. Biol., J. Am. Chem. Soc., Metab. Eng., Proc. Natl. Acad. Sci., etc.

Email:liu_t@tib.cas.cn

7.张大伟，从事工业微生物菌种构建，复杂代谢途径重构与调控解析。利用分子遗传工具、代谢工程与合成生物技术、系统多种组学技术，高通量筛选技术等，实现微生物细胞工厂构建与筛选，合成维生素、氨基酸及其衍生物;构建蛋白表达系统，实现酶蛋白的高效合成;实现微生物细胞工厂的生产化学品与蛋白质工业应用。在Nature Communications，Biosensor and Bioelectronics，mBio等学术刊物上发表SCI论文50余篇，申请专利30余项。

Prof. Dawei Zhang’s research topic is to construct the industrial stains, and study the mechanism of complex metabolism pathway regulation and rewriting. His group integrates genetic manipulation tools, metabolic engineering and synthetic biology techniques, system and omics tools, high throughput screening methods to construct and screen the over-producing stains and to produce vitamins, amino acids and their derivatives. They are also interested in constructing protein production platforms to produce valuable enzymes and proteins. he has published more than 50 papers inNature Communications, ACS Synthetic Biologyand applied 30 patents.

Email:zhang_dw@tib.cas.cn

8.毕昌昊，主要研究方向为合成生物学技术方法的创建与运用，基因组编辑技术研发，以及人工细胞和细胞机器设计构建。合成生物学和基因组编辑技术方法造成较大影响，已有上百个国内外实验室已索取材料并使用。在主流学术期刊Nature Biotechnology，Metabolic Engineering，ACS Synthetic Biology等杂志发表SCI论文40余篇，申请国内和国际专利五项。

Prof.Changhao Bi focus on DNA and genome manipulation techniques for controlling DNA with faster, deeper and bigger fashions.The group has published 40 SCI research articles in Journals likeNat Biotechnol,ACS Synth, Metab Eng, etc. the group has developed a series of genome and base editing techniques in mammalian cells and microbes likeE. coli, Ralstonia eutrophaandBacillus subtilis.More than a hundred labs are using these systems based on the request we have received and record on the Molecular Cloud website.

Email: bi_ch@tib.cas.cn

9.王猛，研究主要方向是实验室自动化在合成生物学领域的应用，以期用自动化技术替代人力完成大量实验。同时关注高通量筛选方法技术的开发应用及复杂天然产物生物合成途径的发现与异源合成。已经在Nat Commun，Trends Biotechnol，Metab Eng等国际一流杂志发表文章28篇，申请专利4项。

Prof.Meng Wang’s research interests focused on lab automation for synthetic biology in order to use robotics replace human labor for massive experiments. He also interested in developing high-throughput screening technologies and complex natural product biosynthetic pathway discovery and heterologous production. He has published 28 papers in journals such as Nat Commun, Trends Biotechnol, Metab Eng. He has applied for 4 patterns.

Email:wangmeng@tib.cas.cn

10.李志超，利用实验进化手段，解析水平基因转移(天然转基因)进化事件的分子机制，借此开发新型的基因递送技术、基因组融合及细胞融合技术;同时致力于开发植物使能技术、构建植物细胞工厂，对微生物合成困难的重要天然植物药物进行植物同源合成。近期研究工作发表于Nature Communications(2018)和Nucleic Acids Research(2019)。

Prof. Zhichao Li’s research topic is to study the mechanism of horizontal gene transfer (natural transgene) by experimental evolution strategy. The aim is to develop the new technology of transgene delivery, genome fusion and cell fusion. We also work on developing the plant enabling technologies and constructing the plant cell factories to produce the plant natural products, which are hard to be synthesized in microbe. Our latest research work is published onNature Communications(2018) andNucleic Acids Research(2019).

Email:lizhch@tib.cas.cn

11.赵磊，从事植物细胞工程与代谢研究，致力于重要功能元件的发掘、设计与模块组装，并综合运用遗传学、细胞生物学、合成生物学等原理和方法，进行植物底盘(番茄、微藻等)细胞的设计改造及应用，以实现高附加值化学品、重组蛋白、天然产物等的绿色生物制造。至今，已在J Cell Biology、Philosophical Transaction B、Plant Physiology、J Integr Plant Biol等杂志上发表文章10余篇，申请国家发明专利12项(10项获授权)。

Prof. Lei Zhao’s research topic is Plant Cell Engineering and Metabolism. By combining genetics, cell biology and synthetic biology, he is committed to the design and application of plant chassis including tomato and microalgae, aiming to produce high value-added products. He has applied 12 patents and published more than 10 papers inJ Cell Biology, Philosophical Transaction Band so on.

Email:zhaol@tib.cas.cn

12.戴住波，主要应用代谢工程和合成生物学技术，建立以高效微生物细胞工厂为基础的天然药物(中药)、精油和营养补充剂生产新模式。研究内容包括通量功能基因克隆与鉴定、新技术开发与应用、产业级微生物细胞工厂构建和化学半合成工艺开发等方面。目前以酿酒酵母为底盘微生物创建了超30个高值天然产物的人工细胞工厂，其中“人参酵母”和“精油酵母”等产品系已实现技术转让。研究成果发表在Metabolic Engineering等学术期刊上，申请专利15项(含PCT 1项)，参编专著5部，丹参酮项目获中国药学会科学技术一等奖。

Prof.Zhubo Dai Professor in Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (TIB, CAS). His research interest is using synthetic biology and metabolic engineering to construct efficient yeast cell factories for production of high-value plant metabolites from renewable biomass. So far, he has published papers in Biotechnology and Bioengineering, Metabolic Engineering and so on, and has applied 15 patents with 4 granted.

Email:dai_zb@tib.cas.cn

13.戴宗杰，从事Crabtree阴性酵母合成生物学与系统生物学研究。利用理性设计构建与基因组编辑进化，结合系统生物学解析，通过设计-构建-测试-学习(DBTL)的方式循环迭代提升酵母底盘的代谢效能。目前研究团队主要研究内容包括：高版本酵母底盘细胞的构建解析，糖醇、萜类及其衍生物的合成，基因组编辑进化策略的开发。主持国家自然科学基金面上项目，中国科学院人才支持项目、天津市创新能力提升行动项目。文章发表于Nat Commun,Curr Opin Biotechnol等，获国内外授权专利3项。

Associate Prof. Zongjie Dai focus on the study of Crabtree negative yeast through synthetic and systems biology. Adapting the rational design-build, genomic edition-evolution and systems biology-based elucidation to improve the metabolic efficiency of yeast chassis within the loop of DBTL. With the funding from NSFC, CAS and Tianjin government, currently, the group has three objectives: 1. The construction and elucidation of highly efficient yeast chassis, 2. Biosynthesis and manufacture of sugar alcohol, terpenoids and related derivatives, 3. Development of strategies for genomic edition and evolution. At present, our works were published inNat Commun,Curr Opin Biotechnol,etc., with 3 authorized patents.

Email: daizj@tib.cas.cn

14.郭晓贤，研究致力于通过对酶的设计改造开发新的DNA生物合成与纠错技术;同时开发线粒体基组遗传工程技术，改造线粒体调控细胞内的代谢流与代谢途径。在Molecular Biology and Evolution，NAR Genomics and Bioinformatics, ACS Synthetic Biology等学术刊物上发表SCI论文10余篇。

Associate Prof. Xiaoxian Guo research interests in the laboratory focus on development of novel technique for enzymatic DNA synthesis and error correction. His lab also interested in engineering mitochondrial genome to manipulate the spatial distribution of metabolic flows. He has published over 10 papers in over 10 scientific articles in international journals, includingMolecular Biology and Evolution, NAR Genomics and Bioinformatics and ACS Synthetic Biology.

Email:guoxx@tib.cas.cn

比方导师(Professor from VIB)：

15. Kevin Verstrepenis professor in Genetics and Genomics at Leuven University, director of the VIB Center for Microbiology, director of the Leuven Institute for Beer Research and Honorary Professor at Nottingham University.Verstrepen obtained his PhD in biological engineering from KU Leuven and a postdoc from MIT.In 2005, Verstrepen was appointed as lecturer at Harvard University, where he led a team of researchers specialized in yeast genetics.In 2007, he was appointed as professor in Genetics at Leuven University and as team leader at VIB, and in 2016, he was appointed as director of the VIB-KU Leuven Center for Microbiology. Verstrepen authored more than 150 publications in various scientific journals and books, including Cell, Science and Nature journals, and received several distinctions, including the Harvard D. Bok Award for teaching, the EMBO Young Investigator award and the Léo Errera prize of the Belgian Academy for Arts and Sciences.

The main research of the Verstrepen lab is focused on yeast genetics, genomics and synthetic biology.Apart from the published research, several of the yeasts that were developed in the lab are now used commercially by various companies, including large breweries, bakeries and biofuel plants.

Email: Kevin.Verstrepen@kuleuven.be

16. Alain Goossensis Professor in Plant Biotechnology at Ghent University and is group leader of the Specialized metabolism group at the VIB-UGent Center for Plant Systems Biology. Goossens received his PhD in Marc Van Montagu’s lab at Ghent University (Belgium) and performed postdoctoral studies at the IBMCP-UPV in Valencia (Spain) in the lab of Ramón Serrano. He started his research group within the VIB in 2003, focusing on jasmonate signaling, gene discovery in plant specialized metabolism and metabolic engineering. He has been appointed as a part-time Full Professor at Ghent University in 2015 and is teaching ‘Metabolic Engineering’. He has authored over 120 peer reviewed publications, including in Nature, Science, etc. In 2020 he was elected as an EMBO fellow and since 2015 he has been included in the prestigious Thomson Reuters list of Highly Cited Researchers.

E-mail: alain.goossens@ugent.vib.be

17. Sibylle Voneschreceived her Ph.D. from ETH Zurich (Switzerland) and is currently a Postdoctoral Fellow in the Systems Genetics and Precision Health Group of Lars Steinmetz at the European Molecular Biology Laboratory in Heidelberg (Germany). Her research focuses on developing cutting edge CRISPR technologies for high-throughput precision genome perturbation, and scalable functional genomics and genome-wide technologies that measure molecular and cellular consequences of genetic perturbations. The group applies these tools to unravel functional roles of genetic variants in the context of complex traits and synthetic biology using the yeastS. cerevisiaeas a model system.She hasauthored 10 publications in various scientific journals, including PLoS Genetics, Nature Communications and Nature Biotechnology. She will start her research group (Genome Editing and Systems Genetics) at the VIB-KU Leuven Center for Microbiology in 2021.

Email:vonesch@embl.de

18. Joleen Masscheleinis an assistant professor at the Department of Biology at KU Leuven and a group leader at the VIB-KU Leuven Center for Microbiology. Her research is focused on discovering novel bioactive natural products from human and plant host-associated bacteria, elucidating unusual pathways for natural product biosynthesis, unravelling the ecological role, biological target and mode of action of natural products, and engineering microbes for the production of novel, industrially relevant natural product derivatives and other therapeutic applications. She has authored more than 20 publications and two patent applications on the chemistry and biology of bioactive natural products in Nature Chemical Biology, Nature Chemistry and other journals.

Email:joleen.masschelein@kuleuven.be

19. Jan Michielsis full Professor at the KU Leuven Faculty of Bioscience Engineering and group leader at the VIB-KU Leuven Center for Microbiology. He obtained a PhD in applied biological sciences from KU Leuven in 1993 and was appointed as professor in 2001. In 2015, he was appointed as Director of the KU Leuven Centre of Microbial and Plant Genetics, and in 2017, he joined the VIB and he was awarded the Francqui Research Professorship. Michiels has authored over 150 articles in international journals with peer review including Molecular Cell, Nature Microbiology, Nature Communications, Nucleic Acids Research, Molecular Biology and Evolution, eLife, the ISME Journal, Nature Reviews Microbiolgy, FEMS Microbiology Reviews, Microbiology and Molecular Biology Reviews and Trends in Microbiology.

Jan Michiels teaches courses on biochemistry, molecular biology, genetics, and bacterial physiology. His research focuses on bacterial genetics, evolution, ecology, interactions and pathogenesis. Fundamental research topics revolve around tolerance to stress and more specifically tolerance to antibiotics. From an applied point of view, the Michiels lab employs synthetic biology and metabolic engineering to create superior bacterial strains for the production of valuable biochemicals and novel antibiotics.

Email:jan.michiels@kuleuven.be

三、招聘岗位(Recruitment posts)

现面向全国招聘10-20名中比联合培养博士后，由中比双方导师联合指导，将分别在中国和比利时联合开展科学研究。

四、应聘条件(Candidate Qualifications)

1.具有合成生物学、微生物学、植物学、生物工程等相关领域科研背景。

2.具有独立科研的工作能力。

3.身心健康、具有良好的沟通能力和团队协作精神。

五、岗位待遇(Post treatment)

1.年薪不高于研究所副研究员标准，优秀者可一事一议;

2.按照研究所规定足额缴纳社保和住房公积金;

3.享受天津市博士后来(留)津专项生活补助5万元，分两年拨付博士后本人;

4.享受滨海新区在站博士后生活补贴15万/年，共两年，拨付博士后本人;

5.优秀者推荐申报国家合成生物技术创新中心特别博士后计划在内的各类型博士后项目，如入选可以获得不少于100万元经费支持;

6.出站留在研究所工作者，可以享受天津市滨海新区20万元安家补助，拨付博士后本人;

7.解决本人及新生子女落入研究所集体户口;

8.完善的职业发展体系和培训体系，提供到海外名校访问、深造等机会。

六、应聘方式 (Application)

符合应聘条件的人员请填写《中国科学院天津工业生物技术研究所岗位申请表》，并提供相关证明材料(学位证书、发表论文情况和以往研究工作总结及其它可以证明本人能力、水平的材料)。请将上述电子版材料发送至邮箱(lu_ln@tib.cas.cn)或直接发送导师邮箱，邮件主题为“应聘导师+应聘岗位”。

附件下载：中国科学院天津工业生物技术研究所岗位申请表.docx

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